Very Good 1057 Reviews
Jetsetter Approved
This Hotel meets our standards
This hotel meets our standards, but we haven't stayed yet


  •  Bar
  •  Free WiFi
  •  Gym
  •  Handicap Accessible
  •  Parking On Site
  •  Pool
  •  Restaurant
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With a stay at Houston Marriott Medical Center/Museum District in Houston (Texas Medical Center), you’ll be convenient to MD Anderson Cancer Center and Houston Zoo. This 4-star hotel is within close proximity of Rice University and Houston Maritime Museum.


Make yourself at home in one of the 395 air-conditioned rooms featuring refrigerators and flat-screen televisions. Premium TV channels and video-game consoles are provided for your entertainment, with wired and wireless Internet access available for a surcharge. Private bathrooms with shower/tub combinations feature complimentary toiletries and hair dryers. Conveniences include phones, as well as complimentary weekday newspapers and coffee/tea makers.

Spa, Wellness & Premium Amenities

Enjoy a range of recreational amenities, including an indoor pool, a spa tub, and a fitness center. Additional amenities at this hotel include complimentary wireless Internet access and gift shops/newsstands. Guests can catch a ride on the shuttle (surcharge), which operates within 2 mi.

Food & Drink

Enjoy a meal at one of the hotel’s dining establishments, which include 2 restaurants and a coffee shop/café. From your room, you can also access room service (during limited hours). Quench your thirst with your favorite drink at a bar/lounge. Buffet breakfasts are available for a fee.

Business & Travel Amenities

Featured amenities include a business center, express check-in, and express check-out. Planning an event in Houston? This hotel has 9044 square feet (840 square meters) of space consisting of conference space and meeting rooms. Self parking (subject to charges) is available onsite.

How to Get There

Houston Marriott Medical Center/Museum District
6580 Fannin Street
Houston, TX 77030 United States


4.5 Very Good 1057 Reviews
Houston Marriott
Reviewed 1 week ago

Nice hotel in the Medical District. Even with construction going on the stay was very pleasant. Rooms were comfy and clean. Breakfast was decent. Location was convenient. Rates were great. Would definitely stay here when I visit again. Shout out to Joy Poulose and Rosy who provided great service at breakfast.

Driscol's restaurtant
Reviewed 3 weeks ago

Andremise and her boss

Ancremise and her boss Orintho Coleman are to be compliented highly for they made an awesome memory for my grandsons' Mike Jr high school graduation. The food was delicious and they were very delighted to serve us.Mike Jr's parents-Mike Rich and Lorelle Rich join me in complimenting Ancremise and Orintho Coleman..I am Cynthia Williams and my husband Scotty Williams are the proud grands of Mike Jr. and we truly love Orintho Coleman. Love and blessings

Nice for business trip, but one major issue
Reviewed 3 weeks ago

I stayed in a 6th floor king room for three nights for business.
Positives: The room was very clean and modernly appointed. I don’t know if this was true of all the rooms, but I liked some aspects of the layout: the entrance led to a small closet-lined hallway that made the room feel almost larger or more “suite-like” than it actually was. The room had a smart TV so you can use your username and password for a number of streaming services (like Netflix) and they would log out of your account upon checkout. Although my interactions with them were fairly minimal, the staff were friendly and helpful.
Negatives: I had kind of a major issue that I am docking the rating a full point for. However the room was set up, the main vent of the room was aimed right at the pillows of the bed. This meant that I was repeatedly blasted in the face by cool or hot air no matter where my head was along the top of the bed. After a night of terrible sleep I had to sleep “backwards” on the bed by rearranging the covers and pillows so I could sleep with my head at the foot of the bed. As I don’t know if this is true in more rooms than this, I won’t knock down the ratings any more for this.
Other: The hotel has two entrances, one on a street side and a covered one that is accessed through a side mid-block entrance-way that is not as obvious. The street side entrance had a lot of construction when I was there so it was difficult to access at times. Most of the ride sharing services we used were not aware of the covered entrance access so there was some difficulty picking up / dropping off with the construction.
Conclusion: This would have been a quite nice and recommended stay had it not been for a poorly aligned vent relative to the bed that messed with my sleep experience. I would think this is not true of all the rooms, but I do not know this for sure.

Hotel and staff
Reviewed 4 weeks ago

I've stayed at this Hotel five times over the past year. The hotel is nice and the location is great. The staff is what makes this hotel the best. It now feels like our second home. Maraceli and Yolanda are super nice at the breakfast at Driscoli's. Thomas is awesome at making margarita's on Tuesday evening in the concierge lounge. Judith in the concierge lounge is the nicest lady. She takes care of many at dinner each evening! There are many other nice staff members at this hotel. I highly recommend staying here, especially if you plan to be in Houston for several days. They have a shuttle service that is awesome. We use it mainly to go to MD Anderson. The staff is very accommodating!

Unique medical service culture
Reviewed 1 month ago

Booked family here for 30 day medical stay. FYI 30+ day stay is tax free. Hotel geared culturally for patients. Connected to major hospitals and professional towers via crosswalks. Get concierge package for 2 free breaks each day and 2 dinners 5 days a week (voucher for appetizers or drink on other 2 days). Delivered an electric recliner for patient. Excellent with extra towels, etc for post surgery patient. Kind and compassionate staff. Feels like a club atmosphere with people healing. Some business travelers