Members Recommend
Very Good 1652 Reviews
Jetsetter Verified
This Hotel meets our standards
Our editors have been here and it has met our standards

What We Love

  • Part hotel, part art museum; the hotel's collection of 21st-century art is outstanding
  • Farm-to-table restaurant Proof on Main offers over 75 KY Bourbons
  • Housed in a historic former tobacco warehouse

What To Know

  • The first hotel in the 21c collection, the property opened in 2006
  • Art-forward design may not appeal to travelers looking for traditional Southern charm
  • It’s a quirky, small hotel


  •  Bar
  •  Free WiFi
  •  Gym
  •  Handicap-accessible
  •  Parking On Site
  •  Pet-friendly
  •  Restaurant
  •  Spa
Disclaimer: This content was accurate at the time the hotel was reviewed. Please check our partner sites when booking to verify that details are still correct.
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Contemporary art hotel in a former tobacco warehouse, with a 24/7 gallery and award-winning restaurant

The Look

There are lots of reasons people open hotels: to make money, to have fun, to satisfy their egos. Laura Lee Brown and Steve Wilson, the owners of the 90-room 21c Museum Hotel, had a different motive: to introduce the world to their vast contemporary art collection and their beloved city of Louisville at the same time. North America’s only museum dedicated solely to art in the 21st century, 21c has 9,000 square feet of gallery space that is free and open to the public 24/7. Art is so essential at 21c that the museum hosts rotating concerts, screenings and even Yoga with Art classes.

Bed and Bath

In keeping with the hotel’s art bent, the rooms are highly design-oriented. High ceilings and large windows are standard, while many rooms feature exposed brick, a reminder of the building’s past life as a tobacco warehouse. Guestrooms offer luxury bedding, but it’s the bizarrely endearing items such as pewter mint julep cups and the hotel’s omnipresent Red Penguin sculptures that remind you that this is a true boutique hotel, with personalized service and modern Southern hospitality.


You don’t have to leave 21c to sample some of the best bourbon in Kentucky: The hotel’s restaurant, Proof on Main, has a bourbon list long enough to be called the Bourbon Library. Even the low end, an Old Rip Van Winkle 10-year-old, is excellent, while the 23-year-old Van Winkle Family Reserve will knock your socks off. Don’t miss the specialties on the cured meat menu, which features ultra-authentic local specialties like Kentucky country ham and pork jowl terrine alongside standards including Tuscan salami.

In the Area

Eight distilleries make up the Kentucky Bourbon Trail, and all are open for tours. From famed Maker’s Mark and Jim Beam to lesser-known Tom Moore and Heaven Hill, these distilleries make 95 percent of Kentucky’s bourbon, and all are close to the city; you might want to spring for a car and driver for the day. Even if you aren’t a baseball fan, the Louisville Slugger Museum & Factory is a worthwhile tour. See the factory floor, then browse the fascinating collection of baseball memorabilia. For the city’s best nightlife, drive — or cab it — to Bardstown Road. There you’ll find quirky bars, cafés and music venues that have nurtured many of the great Louisville bands through the years.

How to Get There

21c Museum Hotel Louisville
700 W Main Street
Louisville, KY 40202 United States


4.5 Very Good 1652 Reviews
Great Hospitality and Intrigue
Reviewed 4 days ago

The Louisville 21C property is one of the most thoroughly enjoyable and artistically immersive experiences that I’ve had to date. The staff was friendly and knowledgeable and I will certainly stay with them again when I return to town.

Love this unique hotel
Reviewed 5 days ago

We have stayed at 21C multiple times and it never disappoints. It's always interesting to see the new art. Plus we love the bar and Proof on Main. We stay here a 3 or 4 times a year and plan on coming back.

Downtown comfort!
Reviewed 7 days ago

While we did not stay here these hotels are worth stopping to see! Each one has a collection of art unique to the property and I believe the exhibits do change. No charge to view the museum part. The bar was very comfortable with some unique drinks. Our bartender was very knowledgeable about the hotel and the unique style this small chain has to their properties. Off to see the property in Nashville next! We will look forward to making a stay with 21c!

Nice one-night getaway
Reviewed 1 week ago

We had a very nice relaxing evening at the C! The room was very comfortable, clean, and well maintained. Will definitely consider going back. The bathroom lighting was especially unique and fun! Well done 21C!

Super Nice
Reviewed 1 week ago

Love the 21c. Super nice with quirks. Get a balcony deck room and you can have a party on it it’s so big. The staff is great, the location can’t be beat. If your visiting the museums or headed to Yums center this is the place.