Members Recommend
Very Good 1486 Reviews
Jetsetter Verified
This Hotel meets our standards
Our editors have been here and it has met our standards

What We Love

  • Part hotel, part art museum; the hotel's collection of 21st-century art is outstanding
  • Farm-to-table restaurant Proof on Main offers over 75 KY Bourbons
  • Housed in a historic former tobacco warehouse

What To Know

  • The first hotel in the 21c collection, the property opened in 2006
  • Art-forward design may not appeal to travelers looking for traditional Southern charm
  • It’s a quirky, small hotel


  •  Bar
  •  Free WiFi
  •  Gym
  •  Handicap-accessible
  •  Parking On Site
  •  Pet-friendly
  •  Restaurant
  •  Spa
Disclaimer: This content was accurate at the time the hotel was reviewed. Please check our partner sites when booking to verify that details are still correct.
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Contemporary art hotel in a former tobacco warehouse, with a 24/7 gallery and award-winning restaurant

The Look

There are lots of reasons people open hotels: to make money, to have fun, to satisfy their egos. Laura Lee Brown and Steve Wilson, the owners of the 90-room 21c Museum Hotel, had a different motive: to introduce the world to their vast contemporary art collection and their beloved city of Louisville at the same time. North America’s only museum dedicated solely to art in the 21st century, 21c has 9,000 square feet of gallery space that is free and open to the public 24/7. Art is so essential at 21c that the museum hosts rotating concerts, screenings and even Yoga with Art classes.

Bed and Bath

In keeping with the hotel’s art bent, the rooms are highly design-oriented. High ceilings and large windows are standard, while many rooms feature exposed brick, a reminder of the building’s past life as a tobacco warehouse. Guestrooms offer luxury bedding, but it’s the bizarrely endearing items such as pewter mint julep cups and the hotel’s omnipresent Red Penguin sculptures that remind you that this is a true boutique hotel, with personalized service and modern Southern hospitality.


You don’t have to leave 21c to sample some of the best bourbon in Kentucky: The hotel’s restaurant, Proof on Main, has a bourbon list long enough to be called the Bourbon Library. Even the low end, an Old Rip Van Winkle 10-year-old, is excellent, while the 23-year-old Van Winkle Family Reserve will knock your socks off. Don’t miss the specialties on the cured meat menu, which features ultra-authentic local specialties like Kentucky country ham and pork jowl terrine alongside standards including Tuscan salami.

In the Area

Eight distilleries make up the Kentucky Bourbon Trail, and all are open for tours. From famed Maker’s Mark and Jim Beam to lesser-known Tom Moore and Heaven Hill, these distilleries make 95 percent of Kentucky’s bourbon, and all are close to the city; you might want to spring for a car and driver for the day. Even if you aren’t a baseball fan, the Louisville Slugger Museum & Factory is a worthwhile tour. See the factory floor, then browse the fascinating collection of baseball memorabilia. For the city’s best nightlife, drive — or cab it — to Bardstown Road. There you’ll find quirky bars, cafés and music venues that have nurtured many of the great Louisville bands through the years.

How to Get There

21c Museum Hotel Louisville
700 W Main Street
Louisville, KY 40202 United States


4.5 Very Good 1486 Reviews
Great stay
Reviewed 2 days ago

From the time we walked through the door, almost every employee was friendly and helpful. The only exception was the hostess in the restaurant. She was not friendly or helpful at all. The overall stay was great.

Reviewed 4 days ago

Everything exceeded our expectations. A relative who had stayed there before recommended it as a choice place for our honeymoon night since our flight to our honeymoon destination wasn't until the next day. The choice was fantastic and we definitely enjoyed our couples package and stay!!!

Great Location
Reviewed 4 days ago

We stayed for quick weekend gateway. Location is great and the hotel and staff are amazing. The art/gallery is unique and adds a different experience during the stay. Rooms were big, clean and comfortable.

I like this olace
Reviewed 5 days ago

You should really try this if you are tired of chain hotels, And go to Proof on Main. Good food and try a Bourbon flight. Sit in the bar and Marrisa will answer any q's you have about the menu. Had a good time even though a business trip by my lonesome. BY the way I don't review things unless I really liked them.

wedding anniversary stay
Reviewed 5 days ago

My husband and I had talked about staying here for several years and finally decided to try 21C for our 41st anniversary. We were not disappointed and felt that we had made the right decision!
The room was very clean, comfortable and well appointed.
Very clean bathroom and shower as well with soft fluffy towels and nice amenities.
Did not eat dinner at Proof on Main----tables looked very close together and the menu did not appeal to my husband so we went elsewhere. Breakfast at the hotel was very good.
Would definitely stay here again!