Very Good 774 Reviews
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What We Love

  • An artistic stay at a unique new property that's part boutique hotel, part art museumThe intriguing and even provocative artwork hanging or standing throughout the property
  • The brand-new hotel itself, located in a historic sksycraper by McKim, Mead & White
  • The location in downtown Lexington, whose cultural scene is on the rise

What To Know

  • Opened in February 2016
  • Lockbox restaurant serves up seasonal, locavore dishes
  • The brand-new property is still perfecting its service; there may be some staff hiccups in the meantime
bathroom property sink mirror Kitchen home countertop cabinetry flooring


A spacious room or suite at a brand-new boutique hotel with its own contemporary art museum

The Lowdown

21c Museum Hotel Lexington has refined hospitality to an art – or rather, lots of it. A perfect addition to its city, which houses a slew of galleries and a renowned ballet company, this brand-new stay is both a boutique hotel and a contemporary gallery itself. Contemporary art appoints every room or public space; it’s as cutting-edge as what you’ll find in cities like Louisville and Cincinnati, whose 21c hotels have fast become TripAdvisor and Condé Nast Traveler favorites.
The collection is curated by a seasoned art-world pro, but it got its sharp redesign by high-profile Deborah Berke Partners. Before that, it was a bank, in a 1914 skyscraper (Lexington’s first) by McKim, Mead & White – the architects behind the Columbia University campus. Old-fashioned details still abound here, and you’ll see them as you explore. Swing by Lockbox restaurant, which retains some of its original marble and plasterwork, and realize you’re not just among works of art – you’re in one.

Rooms and suites

 Your 21c abode is well-stocked, with a sleek Nespresso coffee machine, a 43-in. flat-screen HDTV and bath amenities by MALIN + GOETZ. But all this is secondary to the real star of the show – the original artwork sharing the space. Choose between a spacious Corner King room of 427 square feet, with lots of natural light from windows with two exposures, and a 686-square-foot, one-bedroom Deluxe suite, which also holds a living and dining area, a double vanity and a second TV. 


 Lockbox serves dinner and dessert under the direction of Executive Chef Jonathan Searle, drawing from the flavors and ingredients of surrounding Kentucky. Menus are seasonal, but a sample meal might feature Kentucky silver catp with toasted farro or a roasted-cauliflower soup with brown butter. Dessert options include the olive-oil cake with blood-orange curd and pistachio ice cream, with select liquors and wines available for pairings.It all happens in a space as sleek and sharp as the rest of the hotel, designed by award-winning Deborah Berke Partners, with original marble flooring and decorative plaster from its origins as Lexington’s first skyscraper. And yes, there are art exhibitions on rotation here, too. 


 Downtown Lexington is on the rise (not least because of this hotel), but its evolving cultural scene stands on a solid foundation. This city has offered a variety of dance-related offerings, musical acts and modern-art galleries for years, and there’s some impressive street art to see, as well. Of course, it’s horses that are Lexington’s most famous draw, so make sure to learn about them at Keeneland Race Course, depending on the season, or the popular museum dedicated to the native American Saddlebred. Other highlights include sprawling estates and historic sites in the area, such as Mary Todd Lincoln’s childhood home.

How to Get There

21c Museum Hotel Lexington
167 W Main St
Lexington, KY 40507 United States


4.5 Very Good 774 Reviews
Great stay, as always!
Reviewed 3 hours ago

21c was a great stay, per usual. The staff was friendly and welcoming. The room was clean, comfortable, and beautifully decorated. I ordered in-room dining which was delicious and prompt. It was a quick stay for me so regretfully, I was unable to check out the galleries or fitness room- hopefully next time!

Stayed here one night for our anniversary! Unique hotel, great experience!
Reviewed 4 days ago

This hotel is super unique with an art museum within the hotel. We loved checking out the art. Great hotel staff and service. Ate dinner and breakfast in the hotel restaurant, the Lockbox and It was Delicious. Reasonably priced, great location downtown within walking of lots of bars/restaurants. Highly recommend!

Hotel Beautiful, front desk staff unorganized
Reviewed 6 days ago

The front desk staff messed up our check in experience, were told we had adjoining rooms during check in and when we went upstairs, rooms were not adjoining. Called down and they said “oh sorry I don’t think queen rooms can adjoin”...

Also charged two different cards way more than room, tax & valet.

Great stay at 21c Lexington
Reviewed 6 days ago

We had a great stay at 21c in Lexington. The hotel is beautiful and we loved the art! Service was excellent. The staff was very attentive. They just need to figure out the valet space. Just not enough room. If there was more than a couple of cars waiting to valet, you were stuck in the road blocking traffic.

Fantastic art concept hotel
Reviewed 1 week ago

This hotel is an incredible new concept. Part hotel, part art gallery, you really do get the best of both worlds. A feast for the eyes and a wonderful place to spend your time whether eating, drinking or sleeping. Absolutely recommend staying here.