Very Good 536 Reviews
Jetsetter Approved
This Hotel meets our standards
This hotel meets our standards, but we haven't stayed yet

What To Know

  • Within walking distance of Union Square, Chinatown, and North Beach
  • Free coffee can be found in the lobby each morning and free wine receptions are held at night
  • WiFi comes at an extra cost


  •  Bar
  •  Gym
  •  Handicap Accessible
  •  Parking On Site
  •  Pet-friendly
  •  Restaurant
  •  Spa
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property Lobby living room Suite conference hall recreation room function hall



Serrano Hotel is centrally located in San Francisco, walking distance from Powell and Market Cable Car Turnaround and close to Asian Art Museum of San Francisco. This 4-star hotel is within close proximity of San Francisco Museum of Modern Art and Cable Car Museum.


Make yourself at home in one of the 236 air-conditioned rooms featuring flat-screen televisions. Pay movies and video-game consoles are provided for your entertainment, while wireless Internet access (surcharge) keeps you connected. Private bathrooms with shower/tub combinations feature designer toiletries and hair dryers. Conveniences include phones, as well as laptop-compatible safes and desks.

Spa, Wellness & Premium Amenities

Take advantage of recreation opportunities such as a 24-hour fitness center, or other amenities including wireless Internet access (surcharge) and concierge services.

Food & Drink

Enjoy a satisfying meal at a restaurant serving guests of Serrano Hotel. Quench your thirst with your favorite drink at a bar/lounge. Breakfast is available for a fee.

Business & Travel Amenities

Featured amenities include a 24-hour business center, dry cleaning/laundry services, and a 24-hour front desk. Planning an event in San Francisco? This hotel has 3000 square feet (279 square meters) of space consisting of conference space and a meeting room.

How to Get There

Serrano Hotel
405 Taylor St
San Francisco, CA 94102 United States


Had a Great Stay!

We really enjoyed Hotel Spero! It is in a great location close to public transportation and within walking distance to good restaurants. The room was a bit small, but clean and comfortable. The best part was being greeted by Jairo everyday!! What a great guy!! He is the concierge at the door and always had a huge smile for us and helped with anything we needed. He remembered us by name and treated us like we were old friends! Would love to go back just to visit with Jairo!!

Very nice hotel but....

I spent one night at Hotel Spero and I found the room to be very nice. I booked a king size bed and so it was a very large room. I had two nice size windows that overlooked the street below and tall buildings. The bed was super comfy, and I found the room to be clean and nicely decorated.
The down side was the location, not in a great area but on the border of union square and Tenderloin area which is
"Yuck" forgive the fancy word but not sure how to describe. That is the only bad point I find with this hotel but It would not prevent me from staying there. I felt safe to go down and have a cigarette at night since there was always people coming and going.
They do not have coffee maker in the room which I so not like, however coffee is provided in the lobby in the morning and a water station to fill your water bottle. Overall a nice place.

Horrible Experience
Anfisa S

I originally booked a room with double beds. The couple that was going to stay with us canceled so i asked if i could be switched to a single bed room. They first said no when i called. Then upon check in they said yes they can do it. No smile, no hi, no how are you. The front desk girl just started typing. The. Handed me the keys. When i went upstairs the room they switched me to was right off the elevators and it was the tiniest room i have ever seen. If i knew i would have kept my double bed room. The window looked to another building. It was an awful room and I paid $700 for it. Never once they bothered to tell me anything about the room that they switched me to. I booked this room to celebrate my husband 40th birthday and felt super disappointed. I felt cheated honestly. Then i accidentally left my boots in the room so i called to ask them if they would look or ask about them. They told me that they were going to call me back and never did. I am so upset with this entire hotel staff that i would never recommend anyone to stay here. The service is horrible