Very Good 124 Reviews
Jetsetter Approved
This Hotel meets our standards
This hotel meets our standards, but we haven't stayed yet

What To Know

  • Within walking distance of Union Square, Chinatown, and North Beach
  • Free coffee can be found in the lobby each morning and free wine receptions are held at night
  • WiFi comes at an extra cost


  •  Bar
  •  Gym
  •  Handicap-accessible
  •  Parking On Site
  •  Pet-friendly
  •  Restaurant
  •  Spa
Disclaimer: This content was accurate at the time the hotel was reviewed. Please check our partner sites when booking to verify that details are still correct.
property Lobby living room Suite conference hall recreation room function hall



Serrano Hotel is centrally located in San Francisco, walking distance from Powell and Market Cable Car Turnaround and close to Asian Art Museum of San Francisco. This 4-star hotel is within close proximity of San Francisco Museum of Modern Art and Cable Car Museum.


Make yourself at home in one of the 236 air-conditioned rooms featuring flat-screen televisions. Pay movies and video-game consoles are provided for your entertainment, while wireless Internet access (surcharge) keeps you connected. Private bathrooms with shower/tub combinations feature designer toiletries and hair dryers. Conveniences include phones, as well as laptop-compatible safes and desks.

Spa, Wellness & Premium Amenities

Take advantage of recreation opportunities such as a 24-hour fitness center, or other amenities including wireless Internet access (surcharge) and concierge services.

Food & Drink

Enjoy a satisfying meal at a restaurant serving guests of Serrano Hotel. Quench your thirst with your favorite drink at a bar/lounge. Breakfast is available for a fee.

Business & Travel Amenities

Featured amenities include a 24-hour business center, dry cleaning/laundry services, and a 24-hour front desk. Planning an event in San Francisco? This hotel has 3000 square feet (279 square meters) of space consisting of conference space and a meeting room.

How to Get There

Serrano Hotel
405 Taylor St
San Francisco, CA 94102 United States


4.5 Very Good 124 Reviews
Really nice business hotel
Reviewed 10 hours ago

I would love to stay at the Hotel Spero again. The location is great and the room I had was large and nice. I don't know if all the rooms are this way (this was a handicap access room), but the decor was excellent and there was plenty of space and nice amenities. The location was quiet and the rooms were too.

Cool, unusual property. Clean, quiet, good location
Reviewed 24 hours ago

Really enjoyed my stay. Loved having a quiet room in the middle of the city. Clean, cool decor, welcoming common spaces. Bathroom was on the small side, but manageable. Would definitely stay there again.

Hotel Spero
Reviewed 1 day ago

It was a good time there. The only problem it was this area is more expensive , but I was very happy to stay there. The room was very confortable, big, good pillows and bed, shower good too. The reception and all staff very friendly.

anniversary stay
Reviewed 1 day ago

great location, good price for a weekday! everything was very close in proximity. overall a great place to stay. i would not mine returning to this Hotel! it even has the city escape across the street.

Clean and great location
Reviewed 1 day ago

It was great! Check in and check out was very quick. Staff was real friendly and helpful. Expedia VIP took care of the resort fee. Resort fee included a welcome gift. I like welcome gifts. Lobby and room were clean. Hotel is close to Union Square. Great places to eat around the hotel. Everything is walkable and feels safe.